Found an interesting issue at a site where the router had lost the configuration. I went out, reconfigured the router from a backup and went to save:
ROUTER#wr
startup-config file open failed (Unknown error 0)
And in the log:
*Mar 7 00:56:53.825: %SYS-4-NV_BLOCK_INITFAIL: Unable to initialize the geometry of nvram
*Mar 7 01:00:30.941: %SYS-4-NV_BLOCK_INITFAIL: Unable to initialize the geometry of nvram